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Hemodynamic Effect of Pulmonary Artery Ligation during Pneumonectomy
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Kwang Ho Lee, Hyun Kyo Lim, Eun Sung Jun, Young Bok Lee, Kyung Bong Yoon, Jae Chan Choi, Soon Yul Kim, Ryung Choi
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Korean J Crit Care Med. 2000;15(2):88-92.
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 Abstract
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- BACKGROUND
Pulmonary artery ligation during pneumonectomy increase the pulmonary blood flow of dependent lung and may increase the pulmonary arterial pressure and pulmonary vascular resistance. The purpose of this study is to evaluate the hemodynamic effect of pulmonary artery ligation during pneumonectomy.
METHODS
Nine patients who were supposed to receive pneumonectomy were studied. Hemodynamic measurements were performed following two lung ventilation (TLV), one lung ventilation (OLV), after pulmonary artery ligation and after pneumonectomy.
RESULTS
There is no significant differences in heart rate, systemic arterial pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index and pulmonary vascular resistance index. Arterial oxygen tension significantly reduced during OLV and increased after pulmonary artery ligation and after pneumonectomy.
CONCLUSIONS
These results suggest that pulmonary artery ligation during pneumonectomy may not affect the cardiopulmonary hemodynamics.
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Physiologic Changes Induced with Lipopolysaccharide in Rats
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Kyoung Min Lee, Kwang Ho Lee, Kong Been Im, Jong Taek Park, Young Bok Lee
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Korean J Crit Care Med. 1999;14(2):137-142.
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Abstract
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- BACKGOUND: Bacterial endotoxin or lipopolysaccharide (LPS) is believed to mediate the tissue damage and shock observed in Gram-negative sepsis (GNS) by initiating a cascade of events, including activation of the coagulation, fibrinolytic and complement systems, and release of proinflammatory cytokines. However, the clinical pictures that result from GNS and endotoxin are quite different. The physiologic changes induced with LPS were investigated in this study.
METHODS
Fifty two male Sprague-Dawley rats were injected intraperitoneally with Escherichia coli LPS. Blood samples and bronchoalveolar lavage (BAL) fluid were obtained at baseline and at 2, 4, 8, 16, 24, and 48 hours after injection. Nitrate/nitrite levels were measured from plasma and BAL samples. Lipid peroxide (LPO) levels were measured from plasma. We measured also protein concentration and number of polymorphonuclear leukocytes (PMNL) and macrophages from BAL samples.
RESULTS
Administration of LPS caused significant increase in nitrate/nitrite concentrations of plasma and BAL fluid (p<0.01). ED50 of LPS was 1.76 mg/kg in plasma nitrate/nitrite assay. Plasma LPO levels were increased slightly after administration of LPS, but no statistical significance. Protein concentration was increased significantly (p<0.01) 4 hours after the administration of LPS. LPS induced increase of the number of PMNLs and macrophages of BAL samples significantly (p<0.05).
CONCLUSIONS
LPS increased NO production and alveolar permeability in rats. Also, LPS increased the number of inflammatory cells in the lung.
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Delayed Development of Pulmonary Embolism after Total Hip Replacement: A case report
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Hyun Kyo Lim, Young Bok Lee, Kwang Ho Lee, Chun Gyung Kim, Kyoung Min Lee, Chong Kweon Chung
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Korean J Crit Care Med. 1998;13(2):239-242.
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Abstract
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- Though anticoagulant therapy has been shown to improve outcomes dramatically, pulmonary embolism is a potentially fatal disease. A 82 years old female underwent elective operation for left femur neck fracture under general anesthesia. At the twenty-two postoperative days, she suddenly developed cyanosis with hypotension. She was transferred to intensive care unit and pulmonary embolism was diagnosed by pulmonary perfusion scan and echocardiography. Despite of diagnosis and treatment of pulmonaly embolism, she expired 29 hours after onset of symptom.
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